Here are links that get me through rough days, other than cuteoverload and icanhascheezburger, which you already know about, in all probability.
Evil Mad Scientist Laboratories = what it says on the tin
Neatorama = general weirdness and fun.
Happy LOL Day = beautiful + cute + clever + a dash of eerie sometimes
Skull-A-Day = kinda spooky and cool
Overcompensating = a good webcomic for someone who's never really been a big fan of webcomics
Not Martha = crafty fun, and unusual finds. Although at the moment it features alarming closeups of bacon. Which, hey, maybe that's a plus for you. More power to ya.
Stack the Cats = cute Flash game, with adorable sounds (so mute your volume or put on headphones)
OK, there are some general interest ones. Now it's your turn. Let's see your guilty pleasures, flist.
--***DISCLAIMER: This LJ in no way advocates wasting time at work. As a former victim of coworkers who would not do their damn jobs, the author encourages you to visit these links at designated break times only. Or when it's just really quiet. SRSLY.***---